Trimetrexate (Neutrexin) is a significantly more potent inhibitor of DHFR than trimethoprim (Proloprim), 18 so potent that hematopoietic cells must be protected through the coadministration of leucovorin. Although trimetrexate is significantly less toxic than trimethoprim-sulfamethoxazole, it is also less effective. 21 Because it is administered once daily, trimetrexate can be used in outpatients even though it is given intravenously. To mimic the sequential enzyme blockade provided by trimethoprim-sulfamethoxazole, dapsone (100 mg orally) can be added to the regimen.
The drug addiction problems in Quebec have a prevalence rate of %. The city of Montreal has a prevalence rate of %, which is one of the lowest for a major city in Canada. The estimates were very low in the urban corridor between Toronto and Montreal. This low level of alcohol and drug abuse contrast with the western provinces. The province of Quebec has many problems with cocaine , and opiate based drugs, while the club drug scene is also very strong along with amphetamines, such as speed. When drug tests were conducted at one of Canada’s largest military bases in Valcartier, just north of Quebec City, it was found that 51 people tested positive for cocaine. Out of those tested, 54 people tested positive for marijuana and several had tested positive for amphetamines. The province of Quebec provides many different resources to handle drug addiction, but it is still a major problem throughout the province. That is why we need people to get into a drug rehab center to help with the drug problems in Quebec. There are several residential drug rehabilitation treatments available in Quebec and so there are many choices for an addict in order to get help.